Mother Brain (Japanese: マザーブレイン) is a fictional video game villain created by Nintendo for the Metroid series. She is a large brain with one eye, who sits in a large jar, from which she controls the Space Pirates on Zebes. Mother Brain is killed multiple times by series protagonist Samus Aran. Her Super Metroid design was originally milder than its final version, resembling an "old lady living in an apartment complex" when designed by Toru Osawa. This design was altered by Tomomi Yamane, who gave her an overall more monstrous appearance. She has made several appearances in other media, most notably in the cartoon, Captain N: The Game Master. Since appearing in the Metroid series, she has received positive reception, but her appearance in Captain N: The Game Master was far less well received.