This is all I can think of at the moment, already got DQ6 pre-ordered and waiting. Looking forward to the new Zelda as well. Radiant Historia is one I just recently found out and the more I read about the more interesting it seems. The ability to travel back and forth through time as well as into a alternate timeline, makes it sound like a hybrid of Chrono Trigger and Chrono Cross, for which I'm all for. If I think of anymore I'll post them.
Deus Ex: Human Revolution has my curiosity piqued. Looking forward to LA Noire, The Last Guardian, and Batman: Arkham City. Brink looks interesting, though I'm not totally sold on the hype it's managed to create.
I'll look forward to Uncharted 3 as soon as I'm done making sure it's perfect before it releases ;)
@LittleCactaur I played Brink last August at Quakecon in Dallas. It was pretty awesome. I personally loathe FPS games, but I liked the way you had a virtually endless amount of options to customize your character and weapons.